Definition of an Optimal Cytotoxic T Lymphocyte Epitope in the Latently Expressed Kaposi's Sarcoma-Associated Herpesvirus Kaposin Protein
Identifieur interne : 003473 ( Main/Exploration ); précédent : 003472; suivant : 003474Definition of an Optimal Cytotoxic T Lymphocyte Epitope in the Latently Expressed Kaposi's Sarcoma-Associated Herpesvirus Kaposin Protein
Auteurs : Christian Brander ; Paula O Onnor ; Todd Suscovich ; Norman G. Jones ; Yun Lee ; Dean Kedes ; Don Ganem ; Jeff Martin ; Dennis Osmond ; Scott Southwood [États-Unis] ; Alessandro Sette [États-Unis] ; Bruce D. Walker ; David T. Scadden [États-Unis]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2001.
Abstract
Cytotoxic T lymphocytes (CTL) recognize and kill virus-infected cells and contribute to immunologic control of viral replication. For many herpesviruses (e.g., Epstein-Barr and cytomegalovirus), virus-specific CTL responses can be readily detected in infected persons, but CTL responses against Kaposi’s sarcoma–associated herpesvirus (KSHV) appear to be weak and remain poorly characterized. Using a human leukocyte antigen (HLA) binding motif–based epitope prediction algorithm, we identified 37 HLA-A*0201 binding peptides from 8 KSHV open-reading frames (ORFs). After in vitro stimulation of peripheral blood mononuclear cells from KSHV-infected persons, CTL responses against 1 peptide in the KSHV kaposin protein (ORF K12) were detected in 2 HLA-A*0201–positive subjects. The optimal CTL epitope was identified by HLA restriction analysis and peptide titration assays. These data describe a latent phase viral gene product targeted by CTL that may be relevant for KSHV immunopathogenesis
Url:
DOI: 10.1086/322003
Affiliations:
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Jones</name><affiliation><wicri:noCountry code="subField">Boston;</wicri:noCountry></affiliation></author><author><name sortKey="Lee, Yun" sort="Lee, Yun" uniqKey="Lee Y" first="Yun" last="Lee">Yun Lee</name><affiliation><wicri:noCountry code="subField">Boston;</wicri:noCountry></affiliation></author><author><name sortKey="Kedes, Dean" sort="Kedes, Dean" uniqKey="Kedes D" first="Dean" last="Kedes">Dean Kedes</name><affiliation><wicri:noCountry code="subField">Charlottesville;</wicri:noCountry></affiliation></author><author><name sortKey="Ganem, Don" sort="Ganem, Don" uniqKey="Ganem D" first="Don" last="Ganem">Don Ganem</name><affiliation><wicri:noCountry code="no comma">Howard Hughes Medical Institute and Department of Microbiology and Medicine and</wicri:noCountry></affiliation></author><author><name sortKey="Martin, Jeff" sort="Martin, Jeff" uniqKey="Martin J" first="Jeff" last="Martin">Jeff Martin</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Osmond, Dennis" sort="Osmond, Dennis" uniqKey="Osmond D" first="Dennis" last="Osmond">Dennis Osmond</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Southwood, Scott" sort="Southwood, Scott" uniqKey="Southwood S" first="Scott" last="Southwood">Scott Southwood</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Epimmune, San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Epimmune, San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Walker, Bruce D" sort="Walker, Bruce D" uniqKey="Walker B" first="Bruce D." last="Walker">Bruce D. 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Scadden, AIDS Research Center, Massachusetts General Hospital, 149 13th St., Rm. 5212, Boston</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2001</date><biblScope unit="vol">184</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="119">119</biblScope><biblScope unit="page" to="126">126</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Cytotoxic T lymphocytes (CTL) recognize and kill virus-infected cells and contribute to immunologic control of viral replication. 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These data describe a latent phase viral gene product targeted by CTL that may be relevant for KSHV immunopathogenesis</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Massachusetts</li></region></list><tree><noCountry><name sortKey="Brander, Christian" sort="Brander, Christian" uniqKey="Brander C" first="Christian" last="Brander">Christian Brander</name><name sortKey="Ganem, Don" sort="Ganem, Don" uniqKey="Ganem D" first="Don" last="Ganem">Don Ganem</name><name sortKey="Jones, Norman G" sort="Jones, Norman G" uniqKey="Jones N" first="Norman G." last="Jones">Norman G. Jones</name><name sortKey="Kedes, Dean" sort="Kedes, Dean" uniqKey="Kedes D" first="Dean" last="Kedes">Dean Kedes</name><name sortKey="Lee, Yun" sort="Lee, Yun" uniqKey="Lee Y" first="Yun" last="Lee">Yun Lee</name><name sortKey="Martin, Jeff" sort="Martin, Jeff" uniqKey="Martin J" first="Jeff" last="Martin">Jeff Martin</name><name sortKey="O Onnor, Paula" sort="O Onnor, Paula" uniqKey="O Onnor P" first="Paula" last="O Onnor">Paula O Onnor</name><name sortKey="Osmond, Dennis" sort="Osmond, Dennis" uniqKey="Osmond D" first="Dennis" last="Osmond">Dennis Osmond</name><name sortKey="Suscovich, Todd" sort="Suscovich, Todd" uniqKey="Suscovich T" first="Todd" last="Suscovich">Todd Suscovich</name><name sortKey="Walker, Bruce D" sort="Walker, Bruce D" uniqKey="Walker B" first="Bruce D." last="Walker">Bruce D. Walker</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Southwood, Scott" sort="Southwood, Scott" uniqKey="Southwood S" first="Scott" last="Southwood">Scott Southwood</name></region><name sortKey="Scadden, David T" sort="Scadden, David T" uniqKey="Scadden D" first="David T." last="Scadden">David T. Scadden</name><name sortKey="Scadden, David T" sort="Scadden, David T" uniqKey="Scadden D" first="David T." last="Scadden">David T. Scadden</name><name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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